Somatic recombination may explain linear psoriasis.
نویسنده
چکیده
Linear psoriasis is an uncommon skin disease of so far unknown origin.' Although many cases reported in the past under this diagnosis should today be reclassified as examples ofinflammatory linear verrucous epidermal naevus,2 or as psoriasis superimposing an epidermal naevus,3 there still remain a number of observations that undoubtedly represent true linear psoriasis. 1 4 5 To explain this unusual phenomenon, the following concept is proposed. Psoriasis vulgaris is considered to be a polygenic disorder.6 A subject affected with linear psoriasis is similarly heterozygous for several genes predisposing to psoriasis vulgaris. During early embryogenesis, crossing over would occur in a somatic cell, resulting in exchange of a segment harbouring one of the predisposing genes. (Evidence for somatic crossing over has been provided in animals and plants,7 8 and it seems reasonable to assume that similar events occur in human cells at all stages of life.9 10) In this way, one of the daughter cells may become homozygous for a psoriasis gene, and this would be the stem cell of a clone proliferating in a linear pattern during embryonic development of the skin." For the ultimate manifestation of linear psoriasis, the presence of other predisposing genes as well as environmental factors would be necessary. This would explain why linear psoriasis is mostly absent at birth but develops later in life. In other words, an ordinary additive gene predisposing in the heterozygous state to psoriasis vulgaris would act in the homozygous state, owing to somatic recombination, as a major gene predisposing to linear psoriasis. Alternative somatic mutational events resulting in homozygosity for this allele would be mitotic non-
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عنوان ژورنال:
- Journal of medical genetics
دوره 28 5 شماره
صفحات -
تاریخ انتشار 1991